Comprehensive Trial Design Capabilities

ADDPLAN supports a wide range of adaptive clinical trial designs, providing flexibility and precision across every stage of development. Key design capabilities include:

• Dose Escalation: Compare a fixed rule mTPI escalation trial to a Bayesian logistic regression driven trial for finding the maximum tolerated dose.
• MCP-Mod: Use the Multiple Comparison Procedure and Modeling approach in a dose ranging study to find the best dose to use in a Phase 3 trial.
• Sample Size Re-estimation: Use conditional power to expand the maximum sample size of a trial if results are promising but not conclusive.
• Population Enrichment: Adaptively enrich the enrolling trial population to target the subjects that the treatment helps the most.
• MAMS Trials: Design and compare type I error controlled multiple arm, multiple stage trials in seconds.
• Surrogate endpoints: Use surrogate endpoints to select the best treatments or populations that benefit most when modeling survival data.

These design options allow development teams to explore, compare, and refine trial strategies to ensure maximum efficiency and success.

How ADDPLAN Works

ADDPLAN streamlines adaptive clinical trial planning by allowing users to create, simulate, and compare multiple trial strategies within one simple, powerful platform. Here’s how it works:

• Tried and Tested: Used by regulatory agencies, top pharma companies, and academia, ADDPLAN has been a market leader for clinical trial design software for years.
• Modular Flexibility: Tailored design modules for Multiple Comparison Procedures, Population Enrichment, and Dose-Finding designs.
• Intuitive Interface: A graphical user interface that makes it easy to design, simulate, and analyze complex adaptive trials.
• Speed & Efficiency: Create designs, compare trial strategies, and simulate trials instantly, accelerating development timelines.
• Risk Reduction: Explore and compare trial options across a wide range of outcomes before implementation, reducing costly missteps.

Why ADDPLAN Stands Out

ADDPLAN brings power and precision to trial design - it's a fully supported, commercial-grade platform built to simplify and optimize adative clinical trial design. Here's what makes ADDPLAN stand out:

• Tried and Tested: Used by regulatory agencies, top pharma companies, and academia, ADDPLAN has been a market leader for clinical trial design software for years.
• Modular Flexibility: Tailored design modules for Multiple Comparison Procedures, Population Enrichment, and Dose-Finding designs.‍
• Intuitive Interface: A graphical user interface that makes it easy to design, simulate, and analyze complex adaptive trials.‍
• Speed & Efficiency: Create designs, compare trial strategies, and simulate trials instantly, accelerating development timelines.‍
• Risk Reduction: Explore and compare trial options across a wide range of outcomes before implementation, reducing costly missteps.

ADDPLAN’s Modular Approach

ADDPLAN offers specialized modules that cater to different trial types, giving users greater flexibility in how they design and manage adaptive trials:

• ADDPLAN MC: For Multiple Comparison Procedures, enabling robust multi-endpoint trial designs.
• ADDPLAN PE: For Population Enrichment, optimizing trial design to target key subpopulations.
• ADDPLAN DF: For Dose-Finding Designs (including MCP-Mod), enabling precision dose optimization with regulatory-backed methodologies.

These modules allow users to create custom trial designs that align with specific development goals, from dose optimization to subpopulation targeting.